| Lastest Insider Transactions Of Spyre Therapeutics, Inc. ( SYRE ) | |||||||||
| Symbol | Company Name | Insider Name | Title | Date | Transation | Share | Price | Amount | File Date |
| SYRE | Spyre Therapeutics, Inc. | King-Jones Heidy | See Remarks | 2026-09-01 | Sell | 28,399 | 87.35 | 2,480,529 | 2026-09-03 21:34:14 |
| SYRE | Spyre Therapeutics, Inc. | King-Jones Heidy | See Remarks | 2026-09-01 | Option Exercise | 28,399 | 14.50 | 411,786 | 2026-09-03 21:34:14 |
| SYRE | Spyre Therapeutics, Inc. | Burrows Scott L | Chief Financial Officer | 2026-09-01 | Sell | 25,732 | 88.75 | 2,283,821 | 2026-09-03 21:33:44 |
| SYRE | Spyre Therapeutics, Inc. | Burrows Scott L | Chief Financial Officer | 2026-09-01 | Option Exercise | 7,500 | 14.50 | 108,750 | 2026-09-03 21:33:44 |
| SYRE | Spyre Therapeutics, Inc. | Turtle Cameron | Chief Executive Officer | 2026-09-01 | Sell | 15,000 | 87.29 | 1,309,410 | 2026-09-03 21:33:05 |
| SYRE | Spyre Therapeutics, Inc. | Albers Jeffrey W. | Directior | 2026-08-07 | Sell | 23,000 | 104.53 | 2,404,190 | 2026-08-10 21:31:51 |
| SYRE | Spyre Therapeutics, Inc. | Albers Jeffrey W. | Directior | 2026-08-07 | Option Exercise | 5,000 | 10.39 | 51,950 | 2026-08-10 21:31:51 |
| SYRE | Spyre Therapeutics, Inc. | Burrows Scott L | Chief Financial Officer | 2026-08-03 | Sell | 7,500 | 95.57 | 716,771 | 2026-08-05 21:32:04 |
| SYRE | Spyre Therapeutics, Inc. | Burrows Scott L | Chief Financial Officer | 2026-08-03 | Option Exercise | 7,500 | 14.50 | 108,750 | 2026-08-05 21:32:04 |
| SYRE | Spyre Therapeutics, Inc. | Turtle Cameron | Chief Executive Officer | 2026-08-03 | Sell | 15,000 | 95.51 | 1,432,705 | 2026-08-05 21:31:09 |
| SYRE | Spyre Therapeutics, Inc. | Burrows Scott L | Chief Financial Officer | 2026-07-01 | Sell | 7,500 | 87.74 | 658,040 | 2026-07-02 21:33:59 |
| SYRE | Spyre Therapeutics, Inc. | Burrows Scott L | Chief Financial Officer | 2026-07-01 | Option Exercise | 7,500 | 14.50 | 108,750 | 2026-07-02 21:33:59 |
| SYRE | Spyre Therapeutics, Inc. | Sloan Sheldon | Chief Medical Officer | 2026-07-01 | Sell | 8,334 | 87.70 | 730,896 | 2026-07-02 21:33:02 |
| SYRE | Spyre Therapeutics, Inc. | Sloan Sheldon | Chief Medical Officer | 2026-07-01 | Option Exercise | 8,334 | 27.46 | 228,852 | 2026-07-02 21:33:02 |
| SYRE | Spyre Therapeutics, Inc. | Turtle Cameron | Chief Executive Officer | 2026-07-01 | Sell | 15,000 | 87.69 | 1,315,346 | 2026-07-02 21:32:04 |
| SYRE | Spyre Therapeutics, Inc. | Burrows Scott L | Chief Financial Officer | 2026-06-25 | Sell | 15,000 | 87.13 | 1,307,000 | 2026-06-26 21:31:44 |
| SYRE | Spyre Therapeutics, Inc. | Burrows Scott L | Chief Financial Officer | 2026-06-25 | Option Exercise | 15,000 | 14.50 | 217,500 | 2026-06-26 21:31:44 |
| SYRE | Spyre Therapeutics, Inc. | Fairmount Funds Management LLC | Directior | 2026-06-23 | Sell | 4,684,781 | 85.31 | 399,658,656 | 2026-06-23 21:56:26 |
| SYRE | Spyre Therapeutics, Inc. | HENDERSON MICHAEL THOMAS | Directior | 2026-06-22 | Sell | 20,000 | 100.00 | 2,000,000 | 2026-06-23 21:32:23 |
| SYRE | Spyre Therapeutics, Inc. | Sloan Sheldon | Chief Medical Officer | 2026-06-03 | Sell | 8,333 | 75.00 | 624,975 | 2026-06-03 21:32:02 |
| SYRE | Spyre Therapeutics, Inc. | Sloan Sheldon | Chief Medical Officer | 2026-06-03 | Option Exercise | 8,333 | 27.46 | 228,824 | 2026-06-03 21:32:02 |
| SYRE | Spyre Therapeutics, Inc. | Turtle Cameron | Chief Executive Officer | 2026-06-01 | Sell | 15,000 | 70.43 | 1,056,486 | 2026-06-03 21:31:11 |
| SYRE | Spyre Therapeutics, Inc. | Burrows Scott L | Chief Financial Officer | 2026-06-01 | Sell | 7,500 | 71.06 | 532,937 | 2026-06-03 21:30:41 |
| SYRE | Spyre Therapeutics, Inc. | Burrows Scott L | Chief Financial Officer | 2026-06-01 | Option Exercise | 7,500 | 14.50 | 108,750 | 2026-06-03 21:30:41 |
| SYRE | Spyre Therapeutics, Inc. | HENDERSON MICHAEL THOMAS | Directior | 2026-05-08 | Sell | 80,000 | 74.40 | 5,952,051 | 2026-05-08 21:31:49 |
| SYRE | Spyre Therapeutics, Inc. | Burrows Scott L | Chief Financial Officer | 2026-05-01 | Sell | 12,500 | 71.37 | 892,125 | 2026-05-01 21:35:12 |
| SYRE | Spyre Therapeutics, Inc. | Burrows Scott L | Chief Financial Officer | 2026-05-01 | Option Exercise | 12,500 | 14.50 | 181,250 | 2026-05-01 21:35:12 |
| SYRE | Spyre Therapeutics, Inc. | Sloan Sheldon | Chief Medical Officer | 2026-05-01 | Sell | 78,333 | 71.50 | 5,600,701 | 2026-05-01 21:34:39 |
| SYRE | Spyre Therapeutics, Inc. | Sloan Sheldon | Chief Medical Officer | 2026-05-01 | Option Exercise | 78,333 | 27.46 | 2,151,024 | 2026-05-01 21:34:39 |
| SYRE | Spyre Therapeutics, Inc. | Turtle Cameron | Chief Executive Officer | 2026-05-01 | Sell | 15,000 | 71.37 | 1,070,507 | 2026-05-01 21:34:11 |
| SYRE | Spyre Therapeutics, Inc. | Turtle Cameron | Chief Executive Officer | 2026-04-01 | Sell | 15,000 | 49.33 | 739,912 | 2026-04-03 21:30:43 |
| SYRE | Spyre Therapeutics, Inc. | Sloan Sheldon | Chief Medical Officer | 2026-04-01 | Sell | 7,958 | 50.00 | 397,900 | 2026-04-03 21:30:11 |
| SYRE | Spyre Therapeutics, Inc. | Sloan Sheldon | Chief Medical Officer | 2026-04-01 | Option Exercise | 7,958 | 21.66 | 172,370 | 2026-04-03 21:30:11 |
| SYRE | Spyre Therapeutics, Inc. | Burrows Scott L | Chief Financial Officer | 2026-04-01 | Sell | 7,500 | 49.34 | 370,076 | 2026-04-03 21:29:36 |
| SYRE | Spyre Therapeutics, Inc. | Burrows Scott L | Chief Financial Officer | 2026-04-01 | Option Exercise | 7,500 | 14.50 | 108,750 | 2026-04-03 21:29:36 |
| SYRE | Spyre Therapeutics, Inc. | Burrows Scott L | Chief Financial Officer | 2026-03-03 | Sell | 2,500 | 40.65 | 101,620 | 2026-03-03 21:32:31 |
| SYRE | Spyre Therapeutics, Inc. | Burrows Scott L | Chief Financial Officer | 2026-03-03 | Option Exercise | 2,500 | 14.50 | 36,250 | 2026-03-03 21:32:31 |
| SYRE | Spyre Therapeutics, Inc. | Turtle Cameron | Chief Executive Officer | 2026-03-02 | Sell | 15,000 | 42.19 | 632,866 | 2026-03-03 21:31:30 |
| SYRE | Spyre Therapeutics, Inc. | Turtle Cameron | Chief Executive Officer | 2026-02-02 | Sell | 15,000 | 32.80 | 492,045 | 2026-02-04 21:33:37 |
| SYRE | Spyre Therapeutics, Inc. | Turtle Cameron | Chief Executive Officer | 2026-01-02 | Sell | 15,000 | 30.68 | 460,134 | 2026-01-06 21:36:32 |
| SYRE | Spyre Therapeutics, Inc. | Turtle Cameron | Chief Executive Officer | 2025-12-01 | Sell | 15,000 | 29.02 | 435,356 | 2025-12-03 21:52:20 |
| SYRE | Spyre Therapeutics, Inc. | Turtle Cameron | Chief Executive Officer | 2025-11-03 | Sell | 45,000 | 23.33 | 1,049,778 | 2025-11-05 21:15:05 |
| SYRE | Spyre Therapeutics, Inc. | Burrows Scott L | Chief Financial Officer | 2025-09-02 | Sell | 18,428 | 16.26 | 299,639 | 2025-09-03 18:53:19 |
| SYRE | Spyre Therapeutics, Inc. | Albers Jeffrey W. | Directior | 2024-11-06 | Sell | 6,700 | 36.76 | 246,313 | 2024-11-08 16:53:52 |
| SYRE | Spyre Therapeutics, Inc. | Albers Jeffrey W. | Directior | 2024-10-25 | Sell | 300 | 36.43 | 10,929 | 2024-10-28 16:41:05 |
| SYRE | Spyre Therapeutics, Inc. | Fairmount Funds Management LLC | Directior | 2024-04-25 | Option Exercise | 3,639,680 | 0.00 | 0 | 2024-04-25 16:55:38 |
