| Lastest Insider Transactions Of SPRUCE BIOSCIENCES, INC. ( SPRB ) |
| Symbol | Company Name | Insider Name | Title | Date | Transation | Share | Price | Amount | File Date |
| SPRB | SPRUCE BIOSCIENCES, INC. | Ways Douglas Kirk | Interim Chief Medical Officer | 2025-12-11 | Option Exercise | 1,250 | 0.00 | 0 | 2026-01-21 16:04:35 |
| SPRB | SPRUCE BIOSCIENCES, INC. | Gharib Samir M. | PRESIDENT AND CFO | 2025-12-15 | Option Exercise | 1,009 | 0.00 | 0 | 2025-12-17 16:58:51 |
| SPRB | SPRUCE BIOSCIENCES, INC. | Szwarcberg Javier B. | CHIEF EXECUTIVE OFFICER | 2025-12-11 | Option Exercise | 2,676 | 0.00 | 0 | 2025-12-17 16:56:43 |
| SPRB | SPRUCE BIOSCIENCES, INC. | Szwarcberg Javier B. | CHIEF EXECUTIVE OFFICER | 2025-12-11 | Option Exercise | 2,676 | 0.00 | 0 | 2025-12-17 16:56:43 |
| SPRB | SPRUCE BIOSCIENCES, INC. | Gharib Samir M. | PRESIDENT AND CFO | 2025-12-10 | Option Exercise | 2,414 | 0.00 | 0 | 2025-12-12 19:05:39 |
| SPRB | SPRUCE BIOSCIENCES, INC. | Szwarcberg Javier B. | CHIEF EXECUTIVE OFFICER | 2025-12-10 | Option Exercise | 6,146 | 0.00 | 0 | 2025-12-12 19:03:14 |
| SPRB | SPRUCE BIOSCIENCES, INC. | Gharib Samir M. | PRESIDENT AND CFO | 2025-10-20 | Option Exercise | 2,053 | 0.00 | 0 | 2025-10-22 16:15:07 |
| SPRB | SPRUCE BIOSCIENCES, INC. | Szwarcberg Javier B. | CHIEF EXECUTIVE OFFICER | 2025-10-20 | Option Exercise | 4,784 | 0.00 | 0 | 2025-10-22 16:15:05 |
| SPRB | SPRUCE BIOSCIENCES, INC. | Parkman Healthcare Partners LLC | 10% Owner | 2025-10-06 | Buy | 256 | 17.91 | 4,585 | 2025-10-15 16:32:43 |
| SPRB | SPRUCE BIOSCIENCES, INC. | Parkman Healthcare Partners LLC | 10% Owner | 2025-10-06 | Sell | 257 | 19.14 | 4,920 | 2025-10-15 16:32:43 |
| SPRB | SPRUCE BIOSCIENCES, INC. | Parkman Healthcare Partners LLC | 10% Owner | 2025-10-06 | Buy | 256 | 17.91 | 4,585 | 2025-10-08 20:55:08 |
| SPRB | SPRUCE BIOSCIENCES, INC. | Parkman Healthcare Partners LLC | 10% Owner | 2025-10-06 | Sell | 257 | 19.14 | 4,920 | 2025-10-08 20:55:08 |
| SPRB | SPRUCE BIOSCIENCES, INC. | Charlton Ralph William III | CHIEF MEDICAL OFFICER | 2024-12-10 | Option Exercise | 164,750 | 0.00 | 0 | 2024-12-20 20:30:02 |
| SPRB | SPRUCE BIOSCIENCES, INC. | Charlton Ralph William III | CHIEF MEDICAL OFFICER | 2024-12-10 | Option Exercise | 164,750 | 0.00 | 0 | 2024-12-20 20:30:02 |
| SPRB | SPRUCE BIOSCIENCES, INC. | Gharib Samir M. | PRESIDENT AND CFO | 2024-12-10 | Option Exercise | 229,750 | 0.00 | 0 | 2024-12-20 20:28:58 |
| SPRB | SPRUCE BIOSCIENCES, INC. | Szwarcberg Javier B. | CHIEF EXECUTIVE OFFICER | 2024-12-10 | Option Exercise | 559,500 | 0.00 | 0 | 2024-12-20 20:28:11 |
| SPRB | SPRUCE BIOSCIENCES, INC. | Novo Holdings A/S | 10% Owner | 2024-03-21 | Sell | 465,021 | 0.75 | 350,951 | 2024-03-25 21:45:53 |
| SPRB | SPRUCE BIOSCIENCES, INC. | Novo Holdings A/S | 10% Owner | 2024-03-18 | Sell | 1,794,999 | 0.76 | 1,358,804 | 2024-03-20 20:56:02 |
| SPRB | SPRUCE BIOSCIENCES, INC. | Novo Holdings A/S | 10% Owner | 2024-03-14 | Sell | 1,912,316 | 0.89 | 1,698,902 | 2024-03-18 21:14:13 |
| SPRB | SPRUCE BIOSCIENCES, INC. | Charlton Ralph William III | Chief Medical Officer | 2023-12-14 | Option Exercise | 31,750 | 0.00 | 0 | 2023-12-18 20:17:05 |
| SPRB | SPRUCE BIOSCIENCES, INC. | Gharib Samir M. | President & CFO | 2023-12-14 | Option Exercise | 112,250 | 0.00 | 0 | 2023-12-18 20:16:35 |
| SPRB | SPRUCE BIOSCIENCES, INC. | Szwarcberg Javier B. | Chief Executive Officer | 2023-12-14 | Option Exercise | 111,000 | 0.00 | 0 | 2023-12-18 20:15:50 |
| SPRB | SPRUCE BIOSCIENCES, INC. | Gharib Samir M. | President & CFO | 2023-06-30 | Option Exercise | 75,000 | 0.00 | 0 | 2023-07-05 18:00:08 |
| SPRB | SPRUCE BIOSCIENCES, INC. | O'Donnell Niall | Directior | 2023-02-16 | Buy | 630,400 | 3.17 | 1,998,368 | 2023-05-16 16:08:52 |
| SPRB | SPRUCE BIOSCIENCES, INC. | Novo Holdings A/S | 10% Owner | 2023-02-16 | Buy | 2,208,000 | 3.17 | 6,999,360 | 2023-02-21 16:19:36 |
| SPRB | SPRUCE BIOSCIENCES, INC. | Gharib Samir M. | President & CFO | 2023-01-03 | Option Exercise | 37,500 | 0.00 | 0 | 2023-01-05 20:11:23 |
